IL-13 treatment alters the miRNA signatures (majority of the miRNAs were downregulated: e.g., miR-210, miR-125a-5p, miR-34a, miR-92b, miR-210, etc.) in apical and basal epithelial cell-derived EVs (both early vs. late) are involved in Th2 differentiation and DC maturationNasal lavage sEVs showed decreased expression of miR-34a, miR-92b and miR-210 correlated with airway obstruction in children. The gene discussed is IL13; the disease is Airway obstruction.