Hernández Prada et al. identified compounds that enhance ACE2 activity using conformation-based rational drug discovery strategy and to evaluate whether such compounds reverse hypertension-induced pathophysiology.88 In vitro assays revealed 2 compounds (a xanthenone and resorcinolnaphthalein) that enhanced ACE2 activity in a dose-dependent manner. The gene discussed is ACE2; the disease is Hypertension.