ACE and cardiovascular disorder: ACE-2 is zinc-containing metalloenzyme and a membrane protein expressed in multiple organs such as heart, lungs, intestine, and kidneys.5,16,17 ACE-2 act as a counterbalance to the Angiotensin-converting enzyme (ACE), thus its decreased expression was found to associate with cardiovascular diseases.18–20 Full-length ACE2 consists of an N-terminal peptidase domain (PD) and a C-terminal collectrin-like domain (CLD) that ends with a single transmembrane helix and a ~40-residue intracellular segment.5,21 ACE2 cleaves Ang II to give Ang-(1–7) via the PD.