In cardiac fibrosis, ACE-2 expression was shown to be protective against Ang II-induced and hypertension-induced cardiac fibrosis.41 In liver fibrosis, both Ang 1–7 and ACE-2 provide protection against the development of liver injury and progression to cirrhosis.42 In experimental acute lung injury, ACE-2 also has protective effect associated with reduced levels of Ang II. This evidence concerns the gene ACE2 and hypertensive disorder.