Among the 116 targets, IL-6, VEGFA, TNF, AKT1, MAPK3, CXCL8, IL10, IL1β, MAPK8, JUN and other targets had higher degree values, indicating that these targets might be the core targets of the compound Xuanju capsule against RA, and the corresponding action mechanism was characterized by multiple components and multiple targets. The gene discussed is MAPK8; the disease is rheumatoid arthritis.