In conclusion, based on the network pharmacology methods, the current study found that the compound Xuanju capsule, in the treatment of RA, might mainly act on 116 targets based on IL-6 through 51 active ingredients such as formic acid, quercetin and kaempferol, and then regulated the IL-17 signal pathway, the TNF signal pathway, the Th17 cell differentiation pathway, the Toll receptor signaling pathway, the RA pathway, etc., to further affect the release of the proinflammatory factors and the anti-inflammatory factors, thereby alleviating inflammatory damage and improving bone tissue repair. This evidence concerns the gene TNF and rheumatoid arthritis.