Among the 116 targets, IL-6, VEGFA, TNF, AKT1, MAPK3, CXCL8, IL10, IL1β, MAPK8, JUN and other targets had higher degree values, indicating that these targets might be the core targets of the compound Xuanju capsule against RA, and the corresponding action mechanism was characterized by multiple components and multiple targets. Here, MAPK3 is linked to rheumatoid arthritis.