NLRP3 and glaucoma: In experimental glaucoma, models of chronic IOP elevation by intracameral microbead injection (43), acute IOP elevation by anterior chamber perfusion (21), and optic nerve crush (44) indicated the involvements of NLRP3 inflammasome activation during retina and optic nerve head damage, whereas pharmacological inhibition of NLRP3 (43) and inhibitor of Fas receptor (45) have been suggested as potential neuroprotective therapeutics in glaucoma.