ZAP70 and colorectal cancer: In radiotherapy for colorectal cancer, through RNA extraction and following bioinformatic analysis, overexpressed ZAP70 was found to influence prognostic factors, such as tumor size and lymph node metastasis and differentiation; this finding showed that ZAP70 gene may act as a sensitivity biomarker for radiotherapy in colorectal cancer (Huang et al., 2011).