Furthermore, some recent data indicated that IL-32 induced anti-inflammatory cytokines, such as IL-10 (Kang et al., 2009) and the immunosuppressive molecules such as IDO in macrophages through STAT3 and nuclear factor κB pathway, and promoted multiple myeloma development (Smith et al., 2011; Yan et al., 2019). This evidence concerns the gene IL10 and plasma cell myeloma.