CISD1 and hyperlipidemia: • Suppressing hyperlipidemia: triglyceride↓ and cholesterol ↓;• Suppressing lipogenic gene expression: fatty acid synthase (FAS) ↓;• Enhancing β-oxidation enzyme: carnitine palmitoyltransferase I (CPT1) ↑;• Enhancing mitochondrial function: respiratory control ratio ↑ and mitochondrial membrane potential ↑;• Enhancing mitophagy: Frataxin ↑, Parkin ↑;PINK1 ↑, Beclin1 ↑, LC3-II ↑, p62 ↓, CISD1 ↓, VDAC1 ↑, TOM20 ↓ and HIF-1α↓.