PRKDC and hyperlipidemia: • Suppressing hyperlipidemia: triglycerides ↓ and cholesterol ↓;• Suppressing inflammation: IL-6 ↓, TNF-α↓ and TGF-β↓;• Suppressing oxidative stress: ROS ↓, SOD ↑, GSH-PX ↑ and MDA ↓;• Enhancing mitochondrial function: ATP generation ↑ and mitochondrial respiratory function ↑;• Enhancing mitophagy: DRP ↓, BNIP3 ↑, LC3-II ↑, Beclin1 ↑, Atg5 ↑, DNA-PKcs ↓, p53 ↓ and NR4A1 ↑.