1. NAM protects neurons from oxidative damage and Aβ toxicity2. NAM ameliorates cognitive decline and neuropathology in 3xTgAD mice3. NAM improves mitochondrial function and autophagy-lysosome procession4. NAM increases p-Akt, MAPK/ERK1/2, and CREB signaling pathways. This evidence concerns the gene CREB1 and Mental deterioration.