1. NMN rescues cognitive impairments and suppresses JNK phosphorylation in AD-Tg mice2. NMN decreases the level of Aβ and deposition and changes the processing of APP in AD-Tg mice3. NMN improves inflammatory responses and ameliorates synaptic loss in AD-Tg mice. This evidence concerns the gene MAPK8 and Alzheimer disease.