PLEC and epidermolysis bullosa: Some variations of these genes may lead to slightly different phenotypes for example ITGA4 can cause EB with pyloric atresia (OMIM 226730) and EB of hands and feet (OMIM 131800) and PLEC can cause limb girdle muscular dystrophy type 17 (LGMD; OMIM 613723) and EB simplex (EBS; OMIM 226670, 616487, and 131950).