The aEEG backgrounds in KCNQ2 EE patients normal amplitude with electrographic seizures, and were correlated with long-term neurodevelopmental outcomes; however, the “developmental epileptic encephalopathy” that highlights genetic dysfunction is an independent factor in determining the outcomes despite cases with KCNQ2 seizures being seizure-free beyond newborn age. This evidence concerns the gene KCNQ2 and developmental and epileptic encephalopathy.