Additionally, DCs of humans inflicted with malaria mediated strong immunosuppression through the induction of Indoleamine 2,3-Dioxygenase 1(IDO1) and Lymphocyte Activation Gene 3 (LAG3), which attenuates inflammatory response by decreasing class II antigen presentation (Vallejo et al., 2018). This evidence concerns the gene IDO1 and malaria.