Furthermore, host endothelial receptors ICAM1 and endothelial protein C receptor (EPCR) are used for sequestration in the brain and cause cerebral malaria (Smith et al., 2000), whereas chondroitin sulfate A binding by some variants (Var2CsA) facilitates placenta binding (Fried and Duffy, 1996). The gene discussed is PROCR; the disease is cerebral malaria.