TNK2 and hepatocellular carcinoma: However, the high content of AcK in colon tissue from AS-30D hepatoma-bearing animals did not correlate with a high AcK (Lys) acetylation degree, as was observed in human CRC cell lines, suggesting that in the colon of hepatoma rats, some deacetylations may occur, affecting the AcK acetylation profile (Supplementary Figure 3B).