This presumed interaction of AS-30D hepatoma cells with colon tissue for 5–7 days promoted a significant increase of the colon levels of AcK (8.8 times) and to lesser extent of K-RAS vs. colon from non-cancer-bearing animals, suggesting a change in the colon metabolism induced by hepatoma cells (Figure 3B). The gene discussed is KRAS; the disease is hepatocellular carcinoma.