It is known that overweight and obesity can cause potential changes in hormonal metabolism (insulin, Insulin-like Growth Factor-1 [IGF-1], and sexual steroids), and proteins produced by fatty tissues (adipokines) are also involved in immune regulation (leptin), inflammatory response (TNFα, interleukin-6 [IL-6], and amyloid A), stromal response, and angiogenesis (VEGF-1) as well as extracellular matrix components (collagen type 6 [Col VI]) (6). The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.