Among them, MCODE 1 mainly comprised the mutations of CDK1, KIF2C, KIF18A, CENPA, and PLK1, which take part in the tumorigenesis and progression of liver cancer (Jung et al., 2019; Komatsu et al., 2009; Li et al., 2020; Li et al., 2011; Long et al., 2018; Luo et al., 2018; Wu et al., 2018; Zhang et al., 2015). The gene discussed is PLK1; the disease is liver cancer.