Analyses of functional enrichment of genes co-expressed with DUSP12 in liver-cancer tissues using Metascape showed that these genes were engaged mainly in “histone methylation”, “cullin RING ubiquitin ligase complexes”, “nuclear specks” and “ubiquitin-like protein transferase activity” (Figs. 2B–2E). This evidence concerns the gene CACUL1 and liver cancer.