In their study, Nielsen et al. focused on the analysis of the tumor microenvironment—especially the juxtatumoral, peripheral, lobular, septal, peripancreatic, and regressive stroma compartments—of chemotherapy-naïve (CTN-PC; n = 10) and neoadjuvant treated (NAT-PC; n = 10) pancreatic adenocarcinomas and found that DOG1 was particularly overexpressed in CAFs that were located in close contact to cancer cells (juxtatumoral CAFs). Here, ANO1 is linked to pachyonychia congenita.