Evidence for a functionally active role of DOG1 in pancreatic cancer cells come from four previous studies showing elevated DOG1 expression in pancreatic cancer cell lines and demonstrating that inhibition, knockdown or knockout of DOG1 attenuates cell motility, migration, and proliferation and promotes cell cycle arrest in G0/G1 phase in vitro and in vivo (Crottes et al., 2019; Sauter et al., 2015; Stanich et al., 2011; Mazzone et al., 2012). Here, ANO1 is linked to familial pancreatic carcinoma.