Studies have shown that partial or total inhibition of DOG1 with T16Ainh-A01 and CaCCinh-A01 leads to reduced channel activity, cell viability, cell proliferation, cell migration, increased apoptosis, and cell cycle arrest in G0/G1 phase in GIST and cancer cells of the breast, bladder, head and neck, and esophagus in vitro (Frobom et al., 2019; Guan et al., 2016; Berglund et al., 2014; Duvvuri et al., 2012; Britschgi et al., 2013) and reduced tumor growth of lung, breast, and head and neck carcinomas in vivo (Hu, Zhang & Jiang, 2019; Kulkarni et al., 2017). The gene discussed is ANO1; the disease is gastrointestinal stromal tumor.