Beside p53 acetylation, as a multifunctional agent, Aspirin may exhibit anticancer effects through p53-independent pathways, such as inhibition of cyclin dependent kinases by aspirin metabolites and inhibition of nuclear-κB signaling through direct interactions with IκB kinase in colorectal cancers (Sankaranarayanan et al., 2020). This evidence concerns the gene TP53 and colorectal cancer.