HMGA2 and esophageal squamous cell carcinoma: Moreover, aspirin reduces mTOR signaling by inhibiting the mTOR effectors S6K1 and 4EBP1 in colorectal cancer (Guo et al., 2016) and suppresses esophageal squamous cell carcinoma growth by inhibiting HBXIP and HMGA2 (Wu et al., 2020).