Based on the estimate of hazard ratio, high sepsis score was associated with the increased risk of death (HR = 2.6, P = 0.005), and average sepsis score in the 40 pmol/g-BW RAGE-aptamer-treated group was significantly lower (P = 0.002) than that in the 40 pmol/g-BW control-aptamer-treated group (6.6 ± 1.6 vs. 10.3 ± 2.7). The gene discussed is AGER; the disease is Sepsis.