This present study is aimed at revealing (1) the correlation of activated tRAS and the degree of IDD in the human disc tissue, (2) the potential biological effects of Ang II on human NP cells and related pathological mechanisms in vitro, and (3) the long-term effects of local activated tRAS in the NP tissue on the process of IDD in vivo. This evidence concerns the gene AGT and intervertebral disk degenerative disorder.