The complicated interactions between CXCR7 and other cytokines, the potential positive feedback loop of IL-8-CXCR7, and the intersection of CXCR7-EGFR activation in PCa cells, suggest a specific and potentially therapeutically targetable CXCR7-mediated signaling pathway in PCa. The gene discussed is ACKR3; the disease is posterior cortical atrophy.