PRNP and prion disease: Most of the remaining signatures were found only in the East African dataset: PRNP linked to susceptibility to prion disease in small ruminants (see Greenlee, 2019 for a review), NFATC3 involved in immunity (Minematsu et al., 2011), the milk genes CSN1S1 and CSN1S2 (see Martin et al., 2002), and two genes implicated in altitude adaptation, ADAMTS6 and SUCLG2. This is not surprising as the East African breeds under consideration live at mean altitudes varying from 590 meters in Kenya to 1,633 m in Burundi (Supplementary Table 5).