DIS3L2 and nervous system disorder: Becker et al. (2020) suggested a potential link between the gene DIS3L2 and the gastrointestinal nematode resistance in sheep and postulated that DIS3L2 polymorphisms influence its degradation functions at the oligoU tail and hence modulate immune response to parasite infection. DIS3L2 has also been identified, among genes involved in cancer, cellular function and maintenance, and neurological disease, in West African cattle (Gautier et al., 2009). In Brazilian sheep, De Simoni Gouveia et al. (2017) found it associated with height variation.