Similarly, for pembrolizumab in KEYNOTE 040, the patients were stratified by PD-L1 combined positive score (CPS) and tumor proportion score (TPS), and compared with SoC, a significant advantage was evident in patients with PD-L1 CPS ≥ 1% (8.7 months vs 7.1 months, p = 0.0049) and in those with PD-L1 TPS ≥ 50% (11.6 months vs 6.6 months, p = 0.0014) (14). The gene discussed is CD274; the disease is neoplasm.