- AML bearing specific chromosomal aberrations: it is defined by the presence of specific genetic abnormalities such as inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM(EVI1); -5 or del(5q); -7; -17/abn(17p) (2). This evidence concerns the gene RUNX1 and acute myeloid leukemia.