MECOM and Myelodysplasia: While chromosomes 5 and 7 aberrations are a common cytogenetic feature of trAML (4) and sAML that developed from previous myelodysplasia or myeloproliferative neoplasms (27), abnormalities involving chromosome 3 [inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM(EVI1)] could be related to a distinct (usually de novo) clinical-biological entity (2, 28).