A20 mice infused with LPSlow-macrophages upregulated the expression of fizz1 (found in inflammatory zone-1) gene which is usually associated with the alternatively activated macrophages phenotype (M2 macrophages), in the spleen (p = 0.0005) and in the tumor (p = 0.03) and il10 gene only in the spleen (p = 0.02) compared to untreated A20 mice. The gene discussed is RETNLB; the disease is neoplasm.