recruited 31 Caucasian male adults with type 2 diabetes mellitus from a community in South Australia and found that diet-induced weight loss (either replacement-based low-calorie diet or low-fat, high-protein, reduced-carbohydrate diet) was significantly correlated with the increase of SHBG, while TT and FT alternation was not statistically significant (46). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.