The adjusted smoothed plots suggest that the U-shaped relationship between SUA and the RDW was maintained in females after adjusting for age, hypertension, CHD, platelets, neutrophils, albumin, fasting blood sugar, creatinine, ESR, prothrombin time, lipid-lowering drugs, and antiplatelet drugs (p = 0.006), but there was no significance of U-shaped relationship in men (p = 0.302) (Figure 3). Here, F2 is linked to Hypertension.