A novel treatment targeting MAPK-related pathways has been described to improve motor function in a mouse model of Rett syndrome (Adams et al., 2020), and a BDNF increase in the motor-related cortex has been associated with improvements in motor coordination in the mouse (Krishnan and Nestler, 2008; Inoue et al., 2018). This evidence concerns the gene BDNF and Rett syndrome.