A recent study demonstrated that METTL3 knockdown strongly induces the mitochondrial apoptotic pathways in lung cancer cells by increasing the levels of cleaved caspase3 and PARP (Wei et al., 2019), and Luo et al. (2021) recent reported that METTL3 knockdown induced cell apoptosis and senescence of dental pulp stem cells. The gene discussed is METTL3; the disease is lung cancer.