Neither L-type nor H-type BSE induced significant conversion in PMCA using PrPC substrate from human, TgHu mouse brain and 293 F cultured cells (Barria et al., 2014a, b), in contrast to C-type BSE and human CJD positive controls (Barria et al., 2014a). This evidence concerns the gene PRNP and Creutzfeldt Jacob disease.