SNCA and multiple system atrophy: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder, pathologically characterized by deposition of alpha synuclein-positive glial cytoplasmic inclusions (GCIs) in several specific regions including the striatum, cerebellum, and olivopontine structures (Brettschneider et al., 2017; Krismer et al., 2019).