CSF1R and Huntington disease: For instance, astrocyte reactivity is detected in Huntington’s disease (HD) [45], and we reported resolution of disease-associated astrogliosis with microglial depletion via CSF1R inhibition in HD model mice [73] that is similar to the observed effects of microglial depletion on astrocyte reactivity in the context of methotrexate chemotherapy [61], consistent with the increasingly studied function of microglia as regulators of astrocyte responses.