As expected, established risk factors (myeloid CH, age, sex, ethnicity, smoking status, cholesterol, HbA1C, HDL, LDL, blood pressure, BMI, uACR, hs-CRP and eGFR scores) were associated on univariate analysis with an adverse outcome as defined by a composite endpoint of death, MI, or stroke (Supplementary Table 10). This evidence concerns the gene CRP and Stroke.