These results suggest a possibility that CXCL9/10/11 released from HER2-positive GC cells by T-DXd might attract tumor-infiltrating lymphocytes, which produce a large amount of IFN-γ35,36, leading to activation of immune cells and further enhancement of HLA class I expression on cancer cells (Fig. 5 and Supplementary Fig. S5). The gene discussed is ERBB2; the disease is cancer.