TCGA dataset showed that mRNA expression of CXCL9/10/11 was decreased in HER2-amplified GC tissues as compared with that in HER2-non amplified GC tissues (Fig. 4A), suggesting that mRNA expression of CXCL9/10/11 might be inversely associated with the activity of HER2 signaling in GC. This evidence concerns the gene ERBB2 and gastric cancer.