LDLR and neoplasm: As expected, the Ldlr KO tumors, characterized as Ldlr WT tumors by prominent well-differentiated and dedifferentiated tumor cells areas (Supplementary Fig. 4a, b), showed no increase in Fc(A680)-VH4127 fluorescence (Fig. 4a), thus validating the LDLR-dependent accumulation of the conjugate in PDAC in vivo.