Despite tissue heterogeneity of LDLR levels in this tumor-bearing mouse model (Supplementary Fig. 4d), fluorescence quantitation revealed a selective accumulation of Fc(A680)-VH4127 in Ldlr WT tumors when compared to Fc(A680)-VH4127 values in all other healthy organs, including pancreas (Fig. 4b). This evidence concerns the gene LDLR and neoplasm.