LDLR and neoplasm: In genetically engineered KIC mice (LSL-KrasG12D; Ink4a/Arffl/fl; Pdx1-Cre)11, we showed that LDLR, highly expressed at the cell-surface of PDAC cells, is the major gateway through which the tumor satisfies its cholesterol needs via an increase in cholesterol-carrying LDL uptake10.