High levels of circulating PlGF have been observed in individuals with various diseases such as cancer (breast4, melanoma5, leukemia6), immune diseases (rheumatoid arthritis7, Systemic Lupus Erythematosus8), metabolic syndrome9, coronary artery disease10 and neovascular age-related macular degeneration (nAMD)11. Here, PGF is linked to cancer.