Brains of SAMP8 mice have shown age-associated pathologies in the hippocampus including age-related Aβ deposition, impaired Aβ clearance, age-related aberrant hyperphosphorylation of Tau-like neurofibrillary tangles, increased oxidative stress and gliosis as well as deficits in learning and memory making SAMP8 mouse a valuable model to study AD and other cognitive disorders40,41. The gene discussed is MAPT; the disease is Alzheimer disease.