ZAP70 and autoimmune disease: Since sunitinib is an FDA-approved drug whose safety has been demonstrated in human subjects, we expect that sunitinib has high therapeutic potentials in treating ZAP70 related autoimmune diseases [e.g., hyperactive ZAP70 R360P mutation-mediated autoimmune disease in patients needing allogeneic hematopoietic cell transplantation (HCT)4].