This HTDS assay revealed that Staurosporine, AZD7762, and Sunitinib [an FDA approved drug for renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST)] from the compound library can effectively inhibit the ZAP70 activity. The gene discussed is ZAP70; the disease is gastrointestinal stromal tumor.