Low-density lipoprotein receptor protein 1 (LRP-1) is highly expressed on brain capillary endothelial cells and glioma cells.32–34 Therefore, angiopep-2 (ANG) is a promising ligand to trigger transcytosis.34 It not only traverses the BBB but also targets glioma cells by recognizing LRP-1. This evidence concerns the gene LRP1 and central nervous system cancer.