Interestingly, reduced representation bisulfite sequencing (RRBS) data for 15 of the same T-ALL cell lines (34) revealed that the TET2 promoter was hypermethylated in all but one cell line in which TET2 was silent (Fig. 1H) and showed a tendency toward higher methylation in cell lines in which TET2 expression was reduced (Fig. 1H and SI Appendix, Fig. S1D). This evidence concerns the gene TET2 and acute lymphoblastic leukemia.