Indeed, analysis of global methylation profiles in primary T-ALL cells revealed that TET2-silenced T-ALL cells have a distinct global methylation pattern (Fig. 3D) marked by extreme promoter hypermethylation but also have a tendency toward increased methylation of intergenic cytosine-guanine-dinucleotides (CpGs) (Fig. 3E), contrary to the intergenic hypomethylation observed in most malignancies (45), including T-ALL. This evidence concerns the gene TET2 and acute lymphoblastic leukemia.