TET2 and acute lymphoblastic leukemia: In stark contrast, we again observed up-regulation of TET2, an established TSG in numerous hematopoietic malignancies, in both LOUCY and DND-41 cells (Fig. 4A and SI Appendix, Fig. S6A), highlighting the exceptionality of TET2 silencing and re-expression by DNA demethylating agent 5-aza in T-ALL.