TET2 and acute lymphoblastic leukemia: In contrast, compared to ETP, T-cell–committed primary thymocytes, and double positive primary thymocytes, TET2 expression was repressed (one-sample t test, P < 0.05) or silenced (transcript per million [TPM] < 1) in 71% (42/59) and 17% (10/59) of primary pediatric T-ALL, respectively (Fig. 1E, Lower) (31).