We also tested eight other private (p.S301P, p.Q710Rfs*18, p.V795F), very rare (MAF <10−4; p.A288V) or rare (MAF between 10−4 and 10−2; p.V219I, p.A448V, p.R920K, p.A1032T) TLR7 variants previously reported in patients with critical COVID-19 (33, 34). The gene discussed is TLR7; the disease is COVID-19.