Of the 23 male patients carrying deleterious alleles of TLR7 infected with SARS-CoV-2, the 20 patients who developed severe (n=3) or critical (n=17) COVID-19 were aged 7-71 years (mean: 32.4 years) whereas the three patients who developed asymptomatic, mild, or moderate infection were younger: 5, 5, and 38 years (mean: 16 years). Here, TLR7 is linked to infection.