Interestingly, we found that the APS-1 patient, and the two patients with auto-Abs neutralizing 10 ng/mL IFN-α2 and IFN-ω were able to neutralize all 13 IFN-α subtypes, as were the two patients with neutralizing auto-Abs against IFN-α2. Here, IFNA1 is linked to autoimmune polyendocrine syndrome type 1.