We therefore performed our SARS-CoV-2 assay with 5 pM (~100 pg/mL) or 20 pM (~400 pg/mL) IFN-α2, on five samples from patients with life-threatening COVID-19 and two samples from uninfected elderly individuals with auto-Abs neutralizing 100 pg/mL but not 10 ng/mL IFN-α2. This evidence concerns the gene IFNA2 and COVID-19.