IgM immunoglobulin is also protective against infections (Boes et al., 1998a; Baumgarth et al., 2000, 2005), which are critically important in patients with SCI, as they can modulate neurologic recovery (Failli et al., 2012; Kopp et al., 2017) and constitute the most frequent co-morbidity (DeVivo et al., 1999). This evidence concerns the gene CD40LG and infection.