Regardless of genotype, CD8-replete male mice exposed to DSS displayed significantly increased expression of the same genes upregulated in PD patient colon biopsies—Lcn2, Ptprc, Cd8b, and Snca. Despite similar DAI scores, the inflammatory effects of DSS were somewhat blunted in females, with no significant difference in Ptprc and DSS-induced increases in Cd8b and Snca only in RGS10−/− mice. Here, SNCA is linked to Parkinson disease.