Comparison of striatal protein data from CD8+ T-cell-replete and CD8+ T-cell-depleted cohorts confirmed significant interactions between CD8+ T-cell status and colitis with regard to levels of TH, DAT, and the TH-pSer40:TH ratio but not VMAT2 in male mice (Additional file 15A), indicating that the effect of colitis on these proteins differed significantly when CD8+ T cells were missing. This evidence concerns the gene CD8A and colitis.