SNCA and colitis: Another study detected no neuropathology in wild-type (WT) female mice after 12 weeks of 0.5% DSS, but in their transgenic female littermates overexpressing human mutant (A53T) α-synuclein, this DSS regimen was associated with neuroinflammation, greater accumulation of pathologic α-synuclein, neurodegeneration, and earlier age of onset for motor impairment compared to transgenic mice without colitis [38].