This was exemplified by decreased expression of Csf1r, Ogt and the interferon-responsive transcription factor Ets1. Several genes involved in RNA splicing were downregulated during recovery including Ccnl2, Ddx5, Pnn, Safb2, Sf3b1, Son, Srrm1 and Fus, the latter being an ALS risk gene [61, 62]. This evidence concerns the gene PNN and amyotrophic lateral sclerosis.