Of the 32 OMIM-recognized ALS risk genes that have known murine orthologs, we also noted mildly elevated expression of Anxa11, Ccnf, Chchd10, Optn, Tardbp and Tuba4a expression in cortical microglia in early or late disease, whereas Pfn1 was mildly suppressed in late disease. This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.