CD4 and glioblastoma: For example, the “Type 2 T helper cell” in IS1 was significantly lower than in IS4, “Effector memory CD4 T cell” and “Immature B cell” were significantly higher than those in IS4, which indicated that the poor prognosis of GBM might be related to the activation of “Effector memory CD4 T cell”, “Immature B cell” and the inhibition of “Type 2 T helper cell”.