CD274 and acute myeloid leukemia: As an example, in AML malignancy, AML blasts evade the immune system by recruiting various strategies to include impediment of NK cell cytotoxicity, reduction of tumor antigen expression, enhancement of activated T cell exhaustion, upregulation of anti-apoptotic proteins, upregulation of T cell’s inhibitory ligands like PD-L1, generation of metabolically and immunosuppressive microenvironment, expansion of T-reg cell number, suppression of immune-synapse configuration, and losing the HLA molecules [170–172].