CD8A and triple-negative breast carcinoma: For example, two studies in patients with non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC) have described the presence of CD8 Trm cells expressing integrin αE (ITGAE, encoding CD103) [32], and Savas et al. further found that the gene signature of the CD8 Trm subset significantly correlated with better survival in patients.