CDH1 and neoplasm: While cancer cells can opportunistically follow tracks generated in the matrix by the fibroblasts [22, 23], at least in one example it has been shown that the fibroblasts are linked to tumour cells by heterophilic adhesion of N-cadherin to E-cadherin present on tumour cells, and thus fibroblasts pull the tumour cell clusters rather than have them follow [24].