It is known that GLP-1 has beneficial effects on metabolic parameters in patients with type 2 diabetes such as increase in insulin release, replenishment of insulin stores, pancreatic β-cells proliferation, improvement of insulin sensitivity in skeletal muscle, inhibition of glucagon secretion, decrease in liver gluconeogenesis, decrease in gastric emptying, increase in thermogenesis, reduction of appetite and body weight [70, 71]. This evidence concerns the gene INS and type 2 diabetes mellitus.