We characterized progression of AEP-related pathology in an AD transgenic mice model APPswe/PS1dE9 (APP/PS1) [27], then applied AuNPs-Cy5.5-A&C, which contained AuNPs-Cy5.5-AK and AuNPs-Cy5.5-CABT, to these mice and conducted live brain imaging. The gene discussed is APP; the disease is Alzheimer disease.