The association between nuclear BCL10 expression and patients’ prognosis has been demonstrated in a variety of hematologic malignancies, including our and other investigators’ studies showing Helicobacter pylori-independence (lack of tumor regression after antibiotics treatment) of gastric lymphoma [18, 19, 55–57], the short failure-free survival in ocular adnexal MALT lymphoma [58], and locally aggressive tumors in cutaneous MALT lymphoma [59]. The gene discussed is BCL10; the disease is hematologic disorder.