In 7,12-dimethylbenzanthracene (DMBA)-implantation-induced pancreatic cancer rats, in which the oncogenesis of pancreatic cancer (PC) is mainly triggered by the KRAS mutation-related signaling pathway [46], Guo et al. revealed that Cyclin B1 was upregulated in the DMBA-treated group when compared with the NaCl crystal-treated group through oligonucleotide microarray approaches [47]. This evidence concerns the gene CCNB1 and pachyonychia congenita.