NFKB1 and breast carcinoma: In human breast cancer cells (MCF7 cell lines), we revealed that AKT, activated by tumor necrosis factor-alpha (TNF-α), phosphorylates BCL10 at Ser218 and Ser231, which subsequently forms a complex with BCL3 (containing a nuclear localization signal) to enter the nucleus and further activate NF-κB signaling [20].